Title of article
Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of α-glucosidase inhibitors
Author/Authors
Ajish، نويسنده , , K.R. and Dhanya، نويسنده , , B.P. and Joseph، نويسنده , , Nayana and Priya Rani، نويسنده , , M. and Raghu، نويسنده , , K.G. and Vineetha، نويسنده , , V.P. and Radhakrishnan، نويسنده , , K.V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
6
From page
665
To page
670
Abstract
A new strategy for the synthesis of novel zerumbone derivatives via a regioselective palladium catalyzed decarboxylative coupling reaction using arene carboxylic acids is described. The current methodology involves the repositioning of endocyclic double bond to exocyclic double bond of zerumbone. Preliminary in vitro analysis revealed that most of the newly synthesized derivatives are potent α-glucosidase enzyme inhibitors.
Keywords
Zingiber zerumbet , PALLADIUM , Decarboxylative coupling , ?-Glucosidase inhibitors , Zerumbone
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1887795
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