Title of article
First total synthesis of prunustatin A
Author/Authors
Yamakoshi، نويسنده , , Shuhei and Kawanishi، نويسنده , , Eiji، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
1175
To page
1177
Abstract
In this study, we achieved the first total synthesis of natural prunustatin A (1), a novel inhibitor of glucose-regulated protein 78 (GRP78) expression. A key feature included a 15-membered ring macrocyclization, which was successfully accomplished by employing Shiina macrolactonization using 2-methyl-6-nitrobenzoic anhydride (MNBA) and 4-dimethylaminopyridine (DMAP).
Keywords
GRP78 , Prunustatin A , Macrocyclization , Reformatsky reaction , 15-Membered ring
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888152
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