Title of article
A facile synthesis of the novel thiazolo[3,2-a]pyrimidine derivatives
Author/Authors
Studzi?ska، نويسنده , , Renata and Wr?blewski، نويسنده , , Marcin and Karczmarska-W?dzka، نويسنده , , Aleksandra and Ko?odziejska، نويسنده , , Renata، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
1384
To page
1386
Abstract
2-Bromomethyl- and 2-iodomethyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-5-ones are prepared via the reaction of 3-allyl-2-thiouracil derivatives with bromine or iodine chloride, respectively. The 6-bromo and 6-nitro derivatives are synthesized by an electrophilic substitution at C-6 of the thiazolopyrimidine system. As a result, novel 2,3-dihydrothiazolo[3,2-a]pyrimidin-5-one derivatives are obtained. Hydrogen halide elimination from the 2-halomethyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-5-ones is also reported.
Keywords
organic synthesis , Thiazole ring closure , elimination reaction , Substitution reaction , 2-a]pyrimidine derivatives , 2-a]pyrimidine derivatives
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888238
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