Title of article :
Facile, efficient and eco-friendly synthesis of 5-sulfenyl tetrazole derivatives of indoles and pyrroles
Author/Authors :
Kuhn، نويسنده , , Bruna L. and Fortes، نويسنده , , Margiani P. and Kaufman، نويسنده , , Teodoro S. and Silveira، نويسنده , , Claudio C.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
A concise, two-step eco-friendly approach towards the synthesis of 5-sulfenyl tetrazole derivatives of indoles and pyrroles, is reported. The synthesis comprises the oxone-mediated thiocyanation of the starting heterocycles towards intermediate 3-thiocyanato indoles and 2-thiocyanato pyrroles, and their subsequent treatment with sodium azide in 2-propanol/water under zinc bromide promotion.
Keywords :
5-Sulfenyl tetrazoles , Pyrrole and indole derivatives , Thiocyanation , Eco-friendly functionalization of heterocycles , Zinc bromide promoted reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
