Title of article :
New cytotoxic halogenated sesquiterpenes from the Egyptian sea hare, Aplysia oculifera
Author/Authors :
Hegazy، نويسنده , , Mohamed-Elamir F. and Moustfa، نويسنده , , Alaa Y. and Mohamed، نويسنده , , Abou El-Hamd H. and Alhammady، نويسنده , , Montaser A. and Elbehairi، نويسنده , , Serag Eldin I. and Ohta، نويسنده , , Shinji and Paré، نويسنده , , Paul W.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
Two new sesquiterpenes, oculiferane (1) and epi-obtusane (2) have been isolated and identified from an acetone extract of the digestive gland of the sea hare, Aplysia oculifera. The structures were elucidated by spectroscopic analysis including HREIMS, 1H, 13C, DEPT, 1H–1H COSY, HMQC, and HMBC NMR; the relative configuration was confirmed by X-ray analysis. Compounds 1 and 2 exhibited cytotoxic activity in vitro against several human cancer cell lines with IC50 values in the low μg/ml range.
Keywords :
Aplysia oculifera , Opisthobranch , cytotoxicity , Halogenated sesquiterpenes
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
