Author/Authors :
Zhang، نويسنده , , Li and Zhang، نويسنده , , Chun-Jiang and Zhang، نويسنده , , Dong-Bo and Wen، نويسنده , , Juan and Zhao، نويسنده , , Xiaowei and Li، نويسنده , , Ya and Gao، نويسنده , , Kun، نويسنده ,
Abstract :
A novel alkaloid, 17-nor-excelsinidine (1), possessing an unusual 1-azoniatricyclo [4.3.3.0] undecane moiety was isolated from the twigs and leaves of Alstonia scholaris alongside its biogenetically related strictamine (2). The structure and absolute stereochemistry of compound 1 were rigorously determined by a combination of NMR spectroscopy and X-ray crystallography. The 17-nor-excelsinidine (1) and strictamine (2) showed significant inhibitory activity against herpes simplex virus (HSV) and adenovirus (ADV).
Keywords :
Anti-adenovirus , Anti-HSV , Indole alkaloids , Alstonia scholaris
