Title of article
Novel synthesis of isoxazoline indolizine amides for potential application to tropical diseases
Author/Authors
Zhang، نويسنده , , Yong-Kang and Plattner، نويسنده , , Jacob J. and Zhou، نويسنده , , Yasheen and Xu، نويسنده , , Musheng and Cao، نويسنده , , Jianxin and Wu، نويسنده , , Qingquan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
1936
To page
1938
Abstract
Synthetically challenging isoxazoline indolizine amide compounds were designed and prepared for potential application to tropical diseases. Indolizine core structures were synthesized strategically as common intermediates for efficient derivatization. The chemistry for the syntheses of 8-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)indolizine-5-carboxamide (3) and 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-indolizine-8-carboxamide (4) is described in this Letter.
Keywords
Synthesis , Indolizine , Tropical diseases , Isoxazoline , Parasiticide
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888626
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