Title of article
The accelerated preparation of 1,4-dihydropyridines using microflow reactors
Author/Authors
Baraldi، نويسنده , , Patricia Tambarussi and Noël، نويسنده , , Timothy and Wang، نويسنده , , Qi and Hessel، نويسنده , , Volker، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
2090
To page
2092
Abstract
The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min). Different 1,4-dihydropyridines were prepared in good to excellent isolated yields (45–88% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 trials.
Keywords
multicomponent reaction , Microreactor , Hantzsch reaction , Flow chemistry , Dihydropyridines
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888724
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