Title of article
Acetals: a new organocatalysis chemotype for one-pot enantioselective α-amination
Author/Authors
Msutu، نويسنده , , Ath’enkosi and Hunter، نويسنده , , Roger، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
2295
To page
2298
Abstract
Conditions are described for one-pot Brønsted acid and organocatalysed enantioselective α-amination of acetals and associated functionalities. Of the organocatalysts screened, proline tetrazole gave the highest ee, while aqueous monochloroacetic acid proved to be the best Brønsted acid activator regarding minimizing racemization and maximizing product yield. The reaction opens up the way for using masked carbonyl functionalities in organocatalysis.
Keywords
Enantioselective ?-amination , Proline tetrazole catalyst , Monochloroacetic acid , acetal , Bis-acetal
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1888872
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