Author/Authors :
Swapnil G. Yerande، نويسنده , , Swapnil G. and Shendage، نويسنده , , Deepak M. and Wakchaure، نويسنده , , Prasad B. and Phadtare، نويسنده , , Ganesh R. and Bhoite، نويسنده , , Madhavrao Y. and Gangopadhyay، نويسنده , , Ashok Kumar and Nagarajan، نويسنده , , Kuppuswamy and Rupp، نويسنده , , Richard Helmut، نويسنده ,
Abstract :
Lewis acid catalyzed Fries rearrangement of 2-fluorophenyl acetate (3) was performed on kg scale. The ortho 5 and para 4 isomers obtained were separated in an industrially feasible way. Compound 4 was then converted into fluorinated building block 3-fluoro-4-methoxybenzoyl chloride (1) while compound 5 was converted into 1,2-diethoxy-3-fluorobenzene (2) in high yields.
Keywords :
Lewis acid , acylation , Fries rearrangement , Dakin oxidation , Process development
