Title of article
Hexanes/acetonitrile: a binary solvent system for the efficient monosilylation of symmetric primary and secondary diols
Author/Authors
Wilke، نويسنده , , Burkhardt I. and Dornan، نويسنده , , Mark H. and Yeung، نويسنده , , Jon and Boddy، نويسنده , , Christopher N. and Pinto، نويسنده , , Atahualpa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
2600
To page
2602
Abstract
Symmetric diols are useful compounds in the synthesis of natural products, their value often dependent on their successful monoprotection. A general and simple method for the monosilylation of symmetrical primary and secondary diols is reported. The method exploits the solubility differential of diols and their monosilylated counterparts in a binary hexanes/acetonitrile solvent system.
Keywords
Silylation , Binary solvent system , Symmetric diol , Monoprotection
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889082
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