Title of article
Synthesis of cis-3-arylated cycloalkylamines through palladium-catalyzed methylene sp3 carbon–hydrogen bond activation
Author/Authors
Seki، نويسنده , , Atsushi and Takahashi، نويسنده , , Yoshiaki and Miyake، نويسنده , , Toshiaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
2838
To page
2841
Abstract
Methylene sp3 carbon–hydrogen bond activation of N-picolinoylcycloalkylamines provides a useful method for synthesizing cis-3-arylated cycloalkylamine derivatives. Pd(II) species catalyzed the γ-arylation of N-picolinoylcycloalkylamines with aryl iodides in the presence of silver carbonate to afford cis-3-arylated N-picolinoylalkylamines in up to 87% yield. Hydrolysis of the amide linkage to give the corresponding cis-3-arylated cycloalkylamines was also demonstrated.
Keywords
Arylcycloalkylamine , Carbon–hydrogen bond activation , arylation , Directing group , Palladium catalysis
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889288
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