Author/Authors :
Kuwata، نويسنده , , Kazuaki and Suzuki، نويسنده , , Masashi and Inami، نويسنده , , Yoshikazu and Hanaya، نويسنده , , Kengo and Sugai، نويسنده , , Takeshi and Shoji، نويسنده , , Mitsuru، نويسنده ,
Abstract :
A stereoselective synthesis of scyphostatin hydrophilic moiety was accomplished. Substrate- and reagent-controlled dihydroxylation of tri- and monosubstituted alkenes afforded desired diols, respectively. Chemo- and stereoselective allylation of α-(methoxycarbonyl)cyclohexanone provided allylcyclohexanol. Oxidative cleavage of glycol and subsequent β-elimination of siloxycyclohexanone furnished the desired epoxycyclohexenone.
Keywords :
scyphostatin , Stereoselective dihydroxylation , Stereoselective allylation , Epoxycyclohexenone , Hydrophilic moiety
