Title of article
A metal-free cross-dehydrogenative coupling of N-carbamoyl tetrahydroisoquinoline by sodium persulfate
Author/Authors
Chen، نويسنده , , Wenfang and Zheng، نويسنده , , Hongbo and Pan، نويسنده , , Xinhui and Xie، نويسنده , , Zhiyu and Zan، نويسنده , , Xin and Sun، نويسنده , , Bin and Liu، نويسنده , , Lei-Jun Lou، نويسنده , , Hongxiang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
2879
To page
2882
Abstract
A metal-free cross-dehydrogenative coupling of N-carbamoyl tetrahydroisoquinoline with a variety of CH nucleophiles mediated by Na2S2O8 is developed. The reaction proceeds smoothly to give the coupled product in up to 83% yields. The nucleophile scope is broad, including simple ketones, aldehydes, and aryl rings. The carbamoyl protecting group can be readily removed under mild condition. The use of Na2S2O8 as the sole reagent for the CDC reaction is attractive based on economical and environmental factors.
Keywords
N-Carbamoyl tetrahydroisoquinoline , Peroxydisulfate , Cross-dehydrogenative coupling , Metal-free , CH functionalization
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889335
Link To Document