Title of article
Efficient synthesis of trypsin inhibitor SFTI-1 via intramolecular ligation of peptide hydrazide
Author/Authors
Chen، نويسنده , , Yiqun and Chen، نويسنده , , Chen-Chen and He، نويسنده , , Yao and Yu، نويسنده , , Mu and Xu، نويسنده , , Lin and Tian، نويسنده , , Chang-lin and Guo، نويسنده , , Qing-Xiang and Shi، نويسنده , , Jing and Zhang، نويسنده , , Min and Li، نويسنده , , Yi-Ming، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
2883
To page
2886
Abstract
Cyclic peptide trypsin inhibitor SFTI-1 was synthesized via intramolecular ligation of a linear peptide hydrazide with high yield. This cyclization strategy did not cause epimerization at the C-terminal Arg residue. CD spectrum and NMR spectroscopy analysis demonstrated that well-folded SFTI-1 could be obtained via standard oxidative folding process. Thus, we present a simple and cost-efficient strategy for the synthesis of SFTI-1.
Keywords
Peptide hydrazides , SFTI-1 , Cyclic peptides , Protein chemical synthesis
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889338
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