Jiadifenlactone A, a novel diseco-prezizaane-type sesquiterpenoid from the fruits of Illicium jiadifengpi

Jiadifenlactone A (1), the first example of cleavage of bond [4, 9] of the seco-prezizaane-type sesquiterpenoid with a unique 9-membered ring moiety, together with its biosynthetic related compound 2, were isolated from the fruits of Illicium jiadifengpi. The structure of 1 and its relative configuration were determined by spectroscopic methods and single-crystal X-ray diffraction analysis. The inhibitory rates of compound 1 on the HBeAg and HBsAg expressions were 37.91 ± 2.78% and 17.21 ± 3.78%, respectively.