Commentary on Factors predicting health-related quality of life recovery in patients undergoing surgical treatment for renal tumors: Prospective evaluation using the RAND SF-36 health survey: Novara G, Secco S, Botteri M, De Marco V, Artibani W, Ficarra V

Most newly diagnosed kidney cancers present at localized stages. With appropriate treatments, the cancer-specific survival rates of such patients are extremely high, which makes patientsʹ health-related quality of life (HRQOL) a relevant issue. To date, most of the available studies on HRQOL have been biased by the absence of baseline HRQOL assessments and by retrospective designs. luate the baseline HRQOL of patients with kidney cancer, comparative HRQOL during the first year after surgery, and the prognostic factors predictive of HRQoL recovery. spectively collected the data of all patients undergoing surgery for kidney tumors at a tertiary academic referral center from February 2006 to September 2007. ts underwent nephron-sparing surgery (NSS) or radical nephrectomy (RN). Patients were invited to self-complete the validated, Italian version of the RAND 36-Item Health Survey 1.0 (SF-36) before surgery, 6 months after surgery, and 12 months after surgery. l, 129 consecutive patients were evaluated. No significant differences were found between the baseline scores of our patients and age- and sex-matched normative data for the Italian general population. Comparing the baseline SF-36 scores to those at 6 months and 12 months, there was statistically significant worsening in the physical domains and improvement in the emotional domains (all P < 0.05). About 50%- to 80% of patients returned to baseline scores 6 months and 12 months after surgery. Age, body mass index (BMI), educational level, occupational status, New York Heart Association (NYHA) functional class, tumor mode of presentation, pathologic stage, size, and histologic subtype were associated with 6-month and 12-month return to the baseline HRQOL scores. The main limitation of the study was the lack of a disease-specific questionnaire. atients returned to preoperative HRQoL within 12 months after RN or NSS. Several patient features, clinical variables, and pathologic tumor variables predict the return of HRQOL.