Author/Authors :
Sharma، نويسنده , , Satyasheel and Han، نويسنده , , Sangil and Shin، نويسنده , , Youngmi and Mishra، نويسنده , , Neeraj Kumar and Oh، نويسنده , , Hyunji and Park، نويسنده , , Jihye and Kwak، نويسنده , , Jong Hwan and Shin، نويسنده , , Beom Soo and Jung، نويسنده , , Young-Hoon and Kim، نويسنده , , In Su، نويسنده ,
Abstract :
A rhodium-catalyzed oxidative C2-alkenylation of indoles containing a N-(p-tolyl)carboxamide group with substituted alkynes via CC bond formation and subsequent CN bond cleavage has been described. This protocol represents direct access to C2-alkenylated free (NH)-indoles, which are important building blocks in the synthesis of natural and pharmacological compounds.
Keywords :
Rhodium , Alkynes , C–H functionalization , Olefination , indoles
