Title of article
Nucleophilic substitution of propargyl alcohols with aliphatic alcohols, aliphatic amines and heterocycles catalyzed by 4-nitrobenzenesulfonic acid: a scalable and metal-free process
Author/Authors
Antony Savarimuthu، نويسنده , , S. and Leo Prakash، نويسنده , , D.G. and Augustine Thomas، نويسنده , , S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
3213
To page
3217
Abstract
It is aimed to provide a cost effective p-NBSA catalyzed nucleophilic substitution of propargyl alcohols with alcohols, amines and heterocycles, without employing corrosive and costly metal catalysts, toxic solvents and column chromatography for purification. A systematic study of CC, CN and CO bond formation and efficacy of the scalability have also been confirmed.
Keywords
Sulfonic acids , Heterocycles , Propargyl amine , Propargyl ether , Propargyl alcohol
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889576
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