Title of article
Application of cyclic ketones in MCR: Ugi/amide coupling based synthesis of fused tetrazolo[1,5-a][1,4]benzodiazepines
Author/Authors
Swapnil G. Yerande، نويسنده , , Swapnil G. and Newase، نويسنده , , Kiran M. and Singh، نويسنده , , Bhawani and Boltjes، نويسنده , , André and Dِmling، نويسنده , , Alexander، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
3263
To page
3266
Abstract
Azido-Ugi reaction involving cyclic ketone, primary amine, isonitrile, and azide afforded substituted tetrazole derivatives 5. These intermediates were hydrolyzed to corresponding acid derivatives. EDAC/HOBt mediated amide bond formation of 5 gave fused tetrazolo[1,5-a][1,4]benzodiazepine 6 in high yield and good diversity.
Keywords
Cyclic ketone , Ugi multi component reaction , Ugi/amide coupling , Fused tetrazole-ketopiperazine
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889611
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