Author/Authors :
Liao، نويسنده , , Benren and Ruan، نويسنده , , Libo and Shi، نويسنده , , Min and Li، نويسنده , , Nian and Chang، نويسنده , , Liang and Liu، نويسنده , , Leping and Yang، نويسنده , , Fan and Tang، نويسنده , , Jie، نويسنده ,
Abstract :
An efficient method for preparation of 3-formyl-2-arylbenzo[b]furan derivatives 4 from 3-chloro-2-(2-methoxyaryl)-1-arylprop-2-en-1-one 2 was developed, and the desired product was obtained in good to excellent yields. By converting 2-(2-methoxyphenyl)-3-oxo-3-phenylpropanal 1 to 2, the regioselectivity problem occurring in the reaction when using 1 as the starting material was successfully avoided. Furthermore, a one-pot procedure for the successive demethylation, cyclization, and hydrolysis was evolved, although the intermediate 3-(dibromomethyl)-2-phenylbenzo[b]furan 3a could be isolated. A plausible mechanism was proposed based on some in situ investigations.
