Author/Authors :
Yakushiji، نويسنده , , Fumika and Haramo، نويسنده , , Masako and Miyadera، نويسنده , , Yukari and Uchiyama، نويسنده , , Chihiro and Takayama، نويسنده , , Kentaro and Hayashi، نويسنده , , Yoshio، نويسنده ,
Abstract :
4-Hydroxycoumarin (1) is a useful synthon in synthetic organic chemistry and a basic skeleton of several bioactive compounds. The direct functionalization of 1 with novel catalytic system would provide an efficient meaning for construction of a chemical library. Here, we developed a new catalytic system using palladium(II) acetate for the C3 regioselective mono-arylation of 1. The 3-mono-arylated and the 3,4-disubstituted coumarins were synthesized to enable derivatization. This palladium-catalyzed direct arylation of 1 is effective for rapid diversification and chemical library construction.
Keywords :
palladium catalyst , arylation , 4-Hydroxycoumarin , regioselective , Direct functionalization
