Title of article
Polyketides from the mangrove-derived endophytic fungus Acremonium strictum
Author/Authors
Hammerschmidt، نويسنده , , Lena and Debbab، نويسنده , , Abdessamad and Ngoc، نويسنده , , Tu Duong and Wray، نويسنده , , Victor and Hemphil، نويسنده , , Catalina Perèz and Lin، نويسنده , , WenHan and Broetz-Oesterhelt، نويسنده , , Heike and Kassack، نويسنده , , Matthias U. and Proksch، نويسنده , , Peter and Aly، نويسنده , , Amal H.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
6
From page
3463
To page
3468
Abstract
Five new polyketide derivatives, 6′-hydroxypestalotiopsone C (1), acropyrone (2), bicytosporone D (3), waol acid (4), and pestalotiopene C (5), together with seven known metabolites (6–12), were obtained from extracts of the endophytic fungus Acremonium strictum, isolated from the mangrove tree Rhizophora apiculata. The structures of the isolated compounds were elucidated on the basis of comprehensive NMR and MS analysis. Compounds 6, 7, and 9 showed moderate cytotoxic activity against human cisplatin-sensitive (IC50 values 27.1, 76.2, and 8.3 μM, respectively) and resistant A2780 cell lines (IC50 values 12.6, 30.1, and 19.0 μM, respectively), whereas only 9 exhibited antibacterial activity against Staphylococcus aureus (MIC value 14.3 μM).
Keywords
Acremonium strictum , polyketides , Rhizophora apiculata , cytotoxic activity , Endophytic fungus
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889733
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