Author/Authors :
Akakabe، نويسنده , , Mai and Kumagai، نويسنده , , Keiko and Tsuda، نويسنده , , Masayuki and Konishi، نويسنده , , Yuko and Tominaga، نويسنده , , Akira and Tsuda، نويسنده , , Masashi and Fukushi، نويسنده , , Eri and Kawabata، نويسنده , , Jun، نويسنده ,
Abstract :
A novel linear polyketide, amphirionin-5 (1), has been isolated from the cultivated algal cells of the benthic dinoflagellate Amphidinium sp. (strain KCA09053), and the structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data. Amphirionin-5 (1) resulted in a 282% increase in the proliferation of murine bone-marrow derived stromal ST-2 cells and 320% increase in the proliferation of murine osteoblastic MC3T3-E1 cells.
Keywords :
Polyketide , dinoflagellate , Cell-proliferation promoting activity , Amphidinium
