Title of article
Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity
Author/Authors
Akakabe، نويسنده , , Mai and Kumagai، نويسنده , , Keiko and Tsuda، نويسنده , , Masayuki and Konishi، نويسنده , , Yuko and Tominaga، نويسنده , , Akira and Tsuda، نويسنده , , Masashi and Fukushi، نويسنده , , Eri and Kawabata، نويسنده , , Jun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
3491
To page
3494
Abstract
A novel linear polyketide, amphirionin-5 (1), has been isolated from the cultivated algal cells of the benthic dinoflagellate Amphidinium sp. (strain KCA09053), and the structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data. Amphirionin-5 (1) resulted in a 282% increase in the proliferation of murine bone-marrow derived stromal ST-2 cells and 320% increase in the proliferation of murine osteoblastic MC3T3-E1 cells.
Keywords
Polyketide , dinoflagellate , Cell-proliferation promoting activity , Amphidinium
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1889753
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