Author/Authors :
Dang، نويسنده , , Qun and Zhang، نويسنده , , Zhibo and Tang، نويسنده , , Bingyu and Song، نويسنده , , Yang and Wu، نويسنده , , Ling and Chen، نويسنده , , Tongqian and Bogen، نويسنده , , Stephane and Girijavallabhan، نويسنده , , Vinay and Olsen، نويسنده , , David B. and Meinke، نويسنده , , Peter T.، نويسنده ,
Abstract :
To discover novel nucleosides as potential antiviral agents, 2′-spirolactam and 2′-spiropyrrolidine-containing nucleoside analogs were envisioned. Efficient synthetic routes were developed with an epoxide opening as the key step to establish the quaternary center at the 2′ position, leading to the design and synthesis of uridine analogs 8 and 21, prodrugs 13–16, and cytidine analog 11.
Keywords :
Spiro-lactam , HCV NS5B , nucleoside , Prodrug , Spiro-pyrrolidine
