Author/Authors :
Cheng، نويسنده , , Jie and Zhai، نويسنده , , Hong and Bai، نويسنده , , Jun and Tang، نويسنده , , Jun and Lv، نويسنده , , Ling and Sun، نويسنده , , Bei، نويسنده ,
Abstract :
A convenient and regioselective one-pot synthesis of 3-chloride or 3-bromide quinoline derivatives was achieved through a Grignard addition reaction by alkynyl Grignard regent to o-trifluoroacetyl aniline and a Cu(II)-catalyzed cyclization–halogenation tandem reaction with aqueous HCl or HBr as electrophilic reagent.
Keywords :
Tandem reaction , 3-Halogen quinolines , One-pot , o-Trifluoroacetyl aniline , Copper
