Title of article
Enantioresolution of 2-methoxy-2-(1-naphtyl)propionic acid using diastereomeric salt formation with chiral phenylethylamine
Author/Authors
Kusakari، نويسنده , , Miho and Ohta، نويسنده , , Yurie and Nakagawa، نويسنده , , Hideaki and Katagiri، نويسنده , , Hiroshi and Kijima، نويسنده , , Tatsuro and Murakami، نويسنده , , Satoshi and Matsuba، نويسنده , , Shigeru and Hatano، نويسنده , , Bunpei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
4114
To page
4116
Abstract
An enantioresolution of 2-methoxy-2-(1-naphtyl)propionic acid (MαNP acid) using the diastereomeric salt with chiral (R)-phenylethylamine was achieved to give enantiopure (R)-MαNP acid in 29% yield with >99% ee based on rac-MαNP acid. X-ray crystallographic analysis of diastereomeric salt revealed that (R)-MαNP acid was tightly arranged by four independent hydrogen bonds and one CH–π interaction with (R)-phenylethylamine.
Keywords
Enantioresolution , Diastereomeric salt , Phenylethylamine , Chiral resolving reagent , 2-Methoxy-2-(1-naphtyl)propionic acid (M?NP acid)
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890141
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