Author/Authors :
Kusakari، نويسنده , , Miho and Ohta، نويسنده , , Yurie and Nakagawa، نويسنده , , Hideaki and Katagiri، نويسنده , , Hiroshi and Kijima، نويسنده , , Tatsuro and Murakami، نويسنده , , Satoshi and Matsuba، نويسنده , , Shigeru and Hatano، نويسنده , , Bunpei، نويسنده ,
Abstract :
An enantioresolution of 2-methoxy-2-(1-naphtyl)propionic acid (MαNP acid) using the diastereomeric salt with chiral (R)-phenylethylamine was achieved to give enantiopure (R)-MαNP acid in 29% yield with >99% ee based on rac-MαNP acid. X-ray crystallographic analysis of diastereomeric salt revealed that (R)-MαNP acid was tightly arranged by four independent hydrogen bonds and one CH–π interaction with (R)-phenylethylamine.
Keywords :
Enantioresolution , Diastereomeric salt , Phenylethylamine , Chiral resolving reagent , 2-Methoxy-2-(1-naphtyl)propionic acid (M?NP acid)
