Title of article
BF3·OEt2-catalyzed synthesis of 1-(tetrahydropyran-3-yl)-1,3-dihydroisobenzofuran and trans-fused hexahydropyrano[3,2-c]chromene derivatives
Author/Authors
Syama Sundar، نويسنده , , Ch. and Ramana Reddy، نويسنده , , M. and Sridhar، نويسنده , , B. and Kiran Kumar، نويسنده , , S. and Suresh Reddy، نويسنده , , C. and Reddy، نويسنده , , B.V. Subba، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
4236
To page
4239
Abstract
A novel intramolecular Prins cyclization of (E)-5-(2-(hydroxymethyl)phenyl)pent-4-en-1-ol with aldehydes has been achieved using 10 mol % BF3·Et2O to produce 1-(tetrahydropyran-3-yl)-1,3-dihydroisobenzofuran derivatives in good to excellent yields with high selectivity. Similar type of coupling with salicylaldehydes provides the trans-fused hexahydropyrano[3,2-c]chromene derivatives in excellent yields.
Keywords
CO , Prins cascade cyclization , Aldehydes , BF3·Et2O , CC bond formation
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890225
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