Title of article
Highly regioselective C4-hydrazinylation of 2,4-dichloroquinolines: expedient synthesis of aminoquinoline substituted pyrrolidin-2,5-diones via hydrazinylquinolines
Author/Authors
Senthil Kumar، نويسنده , , Gopal and Zeller، نويسنده , , Matthias and Gonnade، نويسنده , , Rajesh Ghanshyam and Rajendra Prasad، نويسنده , , Karnam Jayarampillai Rajendra، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
4240
To page
4244
Abstract
A new class of hydrazinylquinoline regio-isomers has been synthesized through SNAr reaction of 2,4-dichloroquinolines with hydrazine hydrate. The reaction stops at the mono-substitution product with high regioselectivity at the C4 rather than C2 position of dichloroquinolines. The hydrazinylquinolines were subsequently converted into aminoquinoline substituted pyrrolidin-2,5-diones in the presence of Eaton’s reagent.
Keywords
SNAr reaction , Regioisomers , Hydrazinylquinolines , Pyrrolidin-2 , 5-diones , Eaton’s reagent
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890227
Link To Document