Author/Authors :
Srinivas، نويسنده , , Jada and Singh، نويسنده , , Parvinder Pal and Varma، نويسنده , , Yogesh Kumar and Hyder، نويسنده , , Irfan and Kumar، نويسنده , , Halmuthur M. Sampath، نويسنده ,
Abstract :
A concise four-step efficient synthesis of honokiol 1 in 68% overall yield is described here. The present method involves tetrakis(triphenylphosphine)palladium [Pd(Ph3)4] catalyzed Kumada coupling in two key steps. First coupling generates biaryl backbone intermediate 5 and second generates 2,4′-O-dimethylhonokiol 3. Final demethylation under AlCl3/DMS condition affords honokiol in quantitative yield.
Keywords :
Kumada coupling , Tetrakis(triphenylphosphine)palladium , Honokiol , demethylation
