Synthesis of fused heterocycles via preferential hydroamination of o-haloarylalkynes over N-arylation and successive intramolecular CC bond formation

A tandem approach for the synthesis of fused naphthyridines and isoquinolines via preferential regio- and stereoselective addition of indoles/pyrroles onto o-haloarylalkynes over N-arylation is described. Inexpensive hydroxymethyl benzotriazole has been used as ligand under microwave irradiation. The structure of the product was confirmed by the X-ray crystallographic studies.