Title of article :
Syntheses of 1′,2′-cyclopentyl nucleosides as potential antiviral agents
Author/Authors :
Dang، نويسنده , , Qun and Zhang، نويسنده , , Zhibo and Chen، نويسنده , , Tongqian and Tang، نويسنده , , Bingyu and He، نويسنده , , Xinglin and He، نويسنده , , Shuangsheng and Song، نويسنده , , Yang and Bogen، نويسنده , , Stephane and Girijavallabhan، نويسنده , , Vinay and Olsen، نويسنده , , David B. and Meinke، نويسنده , , Peter T.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Pages :
4
From page :
5092
To page :
5095
Abstract :
To discover novel nucleosides as potential antiviral agents, 1′,2′-cyclopentyl nucleosides were designed as hybrids of sofosbuvir and GS-6620. An asymmetric aldol condensation reaction was used as the key transformation to prepare the versatile 1′,2′-cyclopentyl ribose 6, which is useful to explore diverse bases at 1′ and its utility was demonstrated via the syntheses of nucleosides 9 and 11. The 2′-β-methyl-1′,2′-cyclopentyl ribonucleoside scaffold was exemplified via a C-nucleoside which was prepared using a RCM reaction as the key step leading to novel nucleoside 35.
Keywords :
Antiviral agents , HCV NS5B inhibitor , C-nucleoside , nucleoside , RCM reaction , Aldol condensation
Journal title :
Tetrahedron Letters
Serial Year :
2014
Journal title :
Tetrahedron Letters
Record number :
1890599
Link To Document :
بازگشت