Title of article
Aryl methyl sulfides via SNAr using DMSO as the source of the thiomethyl moiety
Author/Authors
Jones-Mensah، نويسنده , , Ebenezer and Magolan، نويسنده , , Jakob، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
5323
To page
5326
Abstract
A unique synthesis of aryl methyl sulfides is reported proceeding via reduction of dimethylsulfoxide to dimethylsulfide at elevated temperature in the presence of Hunig’s base followed by nucleophilic aromatic substitution and demethylation. Activated aryl fluorides, chlorides, and nitrobenzenes are suitable substrates with 13 examples provided. Dimethylsulfoxide serves as a simple and inexpensive formal source of the thiomethyl moiety.
Keywords
Dimethylsulfoxide , nucleophilic aromatic substitution , Methyl sulfides , Thiomethyl , Hunig’s base
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890720
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