An efficient synthesis of O-aryloxime ethers by copper fluorapatite catalyzed cross-coupling of aryloximes with arylboronic acids

A novel, highly efficient, and mild protocol has been developed for the synthesis of O-aryloxime ethers in good to excellent yields at ambient reaction conditions. This is the first report in which NOAr linkage was achieved with ecofriendly, recyclable, heterogeneous copper fluorapatite (CuFAP) catalyst via CO cross coupling of aryloxime with arylboronic acid in the presence of Cs2CO3 as base and methanol as solvent.