Title of article
An efficient synthesis of 3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline, a promising radioprotector for cancer radiotherapy
Author/Authors
Wu، نويسنده , , Haitao and Coble، نويسنده , , Vincent and Vasalatiy، نويسنده , , Olga and Swenson، نويسنده , , Rolf E. and Krishna، نويسنده , , Murali C. and Mitchell، نويسنده , , James B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
2
From page
5570
To page
5571
Abstract
Nitroxides can ameliorate the toxic effects of radiation during cancer therapy. Nitroxides are paramagnetic and can be used in magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI) to monitor in vivo oxidative stress status. Compound 5 (3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline) was found to be the most effective nitroxide radioprotector. An efficient synthesis for this promising radioprotector was developed.
Keywords
MRI , EPRI , Radioprotector , Nitroxide , redox
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890829
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