A new approach to the synthesis of cross-conjugated cyclopentenone prostaglandins. Synthesis of (±)-15-deoxy-Δ12,14-prostaglandin J2 methyl ester

A new approach to 15-deoxy-Δ12,14-prostaglandin J2 and related structures based on the (±)-Corey lactone diol has been developed. The key stage of this approach involves building the structure of a prostaglandin (PG) derivative with leaving groups at positions 9, 13, and 15, followed by elimination of these groups by treatment with an organic base.