Author/Authors :
Yang، نويسنده , , Xinzhou and Wang، نويسنده , , Chao and Yang، نويسنده , , Chuan-Jing and Wan، نويسنده , , Dingrong and Lin، نويسنده , , Qinxiong and Yang، نويسنده , , Guangzhong and Mei، نويسنده , , Zhinan and Feng، نويسنده , , Yunjiang، نويسنده ,
Abstract :
Two new eudesmane-type sesquiterpenes, 9α-hydroxycurcolonol (1) and 3α-hydroxy-4-deoxy-5-dehydrocurcolonol (2), along with nine known sesquiterpenes (3–11), were isolated from the roots of Chloranthus angustifolius. The antimicrobial activities of compounds 1–11 were evaluated against five bacteria and six fungal strains. Compounds 6–11 showed potent activities against Candida albicans with MIC values ranging from 4 to 8 μg/mL. The structures of the two new compounds 1 and 2 were established by a detailed analysis of their NMR and mass spectroscopic data.
Keywords :
Eudesmane sesquiterpenes , Antimicrobial , Traditional Chinese Medicine , Chloranthus angustifolius
