Title of article
Total synthesis of AI-77-B
Author/Authors
Rao، نويسنده , , Maddimsetti Venkateswara and Rao، نويسنده , , Batchu Venkateswara and Ramesh، نويسنده , , Bokka، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
5921
To page
5924
Abstract
A new stereoselective approach for the synthesis of AI-77-B has been described. Dihydroisocoumarin fragment was made in two routes using Heck reaction followed by oxidation of the olefin and LDA mediated reaction. The chiral amino acid moiety has been obtained from d-ribose involving Grignard reaction on ribosylimine. Finally, condensation of dihydroisocoumarin with acid fragment furnished the title target AI-77-B.
Keywords
Heck reaction , Dihydroisocoumarin , Total synthesis of AI-77-B , LDA mediated reaction , Grignard addition
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890976
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