Title of article
Glyoxylic acid in the reaction of isatoic anhydride with amines: a rapid synthesis of 3-(un)substituted quinazolin-4(3H)-ones leading to rutaecarpine and evodiamine
Author/Authors
Rao، نويسنده , , K. Raghavendra and Raghunadh، نويسنده , , Akula and Mekala، نويسنده , , Ramamohan and Meruva، نويسنده , , Suresh Babu and Pratap، نويسنده , , T.V. and Krishna، نويسنده , , T. and Kalita، نويسنده , , Dipak and Laxminarayana، نويسنده , , Eppakayala and Prasad، نويسنده , , Bagineni and Pal، نويسنده , , Manojit، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
6004
To page
6006
Abstract
A dual reactant/catalyst role of glyoxylic acid in the reaction of isatoic anhydride with various amines afforded a novel, robust and rapid synthesis of 3-(un)substituted quinazolin-4(3H)-ones. This metal catalyst-free reaction proceeds via an unusual and unexpected cleavage of C–C bond. A shorter and common route to two alkaloids, that is, rutaecarpine and evodiamine is also accomplished.
Keywords
Amine , Glyoxylic acid , Isatoic anhydride , Rutaecarpine , Evodiamine
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891030
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