Title of article
Synthesis of several novel 14-membered ketolides bearing modified 5-O-4′-[1,2,3] triazol desosamine side chain
Author/Authors
Chen، نويسنده , , Xiaozhuo and Xu، نويسنده , , Yanpeng and Zhao، نويسنده , , Zhehui and Lei، نويسنده , , Pingsheng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
6128
To page
6130
Abstract
4-Azido modified desosamine 4a was synthesized and coupled to erythronolide 9. Using trichloroacetimidate donor in the presence of TMSOTf was considered as the most efficient condition for the glycosylation reaction. Five novel 14-membered ketolides 12a–e bearing modified 5-O-4′-[1,2,3] triazol desosamine side chain were synthesized by the azide/alkyne click chemistry method.
Keywords
Desosamine , Ketolide , click chemistry , glycosylation , antibiotics
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891100
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