Title of article
First total synthesis of piperodione and analogs
Author/Authors
Andrea and Sommerwerk، نويسنده , , Sven and Kern، نويسنده , , Simone and Heller، نويسنده , , Lucie and Csuk، نويسنده , , René، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
2
From page
6243
To page
6244
Abstract
Piperodione (3), a secondary metabolite previously isolated from the Javanese pepper plant Piper retrofractum in 0.0002% isolated yield was synthesized in a convergent strategy utilizing a Mannich and a Stetter reaction. An over-all yield of 76% could be achieved. Several analogs were prepared by this synthetic sequence. None of the compounds showed a significant cytotoxicity for human tumor cells (photometric sulforhodamine B assay).
Keywords
SRB assay , Stetter reaction , Mannich reaction , Piperodione , cytotoxicity
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891148
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