Title of article
Pr(OTf)3-promoted Chichibabin pyridine synthesis of isodesmosine in H2O/MeOH
Author/Authors
Sugimura، نويسنده , , Takanori and Komatsu، نويسنده , , Akira and Koseki، نويسنده , , Yohei and Usuki، نويسنده , , Toyonobu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
6343
To page
6346
Abstract
1,2,3,5-Tetrasubstituted pyridinium amino acid isodesmosine is a crosslinking amino acid of elastin and is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). Herein, we report an application of the Chichibabin pyridine synthesis to the total synthesis of isodesmosine. Specifically, the appropriate protected lysine and the corresponding aldehyde were reacted using Pr(OTf)3 in H2O/MeOH.
Keywords
Isodesmosine , Chichibabin pyridine synthesis , total synthesis , Pr(OTf)3
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891190
Link To Document