Title of article
A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki–Miyaura cross-coupling reaction
Author/Authors
Sophie Vichier-Guerre، نويسنده , , Sophie and Dugué، نويسنده , , Laurence and Pochet، نويسنده , , Sylvie، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
6347
To page
6350
Abstract
A simple and rapid access to a variety of 4(5)-arylated imidazoles via palladium-catalyzed Suzuki–Miyaura cross-coupling reaction is described. Coupling parameters were screened for efficient C-4 arylation of N-unprotected 4-iodoimidazole with a broad range of boronic acids under microwave irradiation. Twenty-one imidazole derivatives were synthesized in modest to excellent yields in short reaction times.
Keywords
Suzuki–Miyaura cross-coupling , Boronic acids , 4(5)-Arylimidazoles , Microwave assisted synthesis , C-arylation
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891192
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