Author/Authors :
Ukhin، نويسنده , , Lev Yu. and Akopova، نويسنده , , Arina R. and Morkovnik، نويسنده , , Anatolii S. and Suponitzky، نويسنده , , Kirill Yu. and Shepelenko، نويسنده , , Evgenii N. and Bicherov، نويسنده , , Alexander V. and Popov، نويسنده , , Leonid D.، نويسنده ,
Abstract :
A convenient, one-pot synthesis of N-isatinylmethylthioacetic acid and several of its derivatives, as potential anticancer agents, by reactions of N-(hydroxymethyl)isatins with Bunte salts in TFA is described. The reactions involve attack of these salts on the S(II) atom by C-electrophilic species generated from hydroxy derivatives.
Keywords :
Isatins , N-(Hydroxymethyl)isatins , Potential anticancer isatins , S-desulfo-substitution , Bunte salts
