Author/Authors :
Kim، نويسنده , , Chung Sub and Shin، نويسنده , , Bora and Kwon، نويسنده , , Oh Wook and Kim، نويسنده , , Sun Yeou and Choi، نويسنده , , Sang Un and Oh، نويسنده , , Dong Chan and Kim، نويسنده , , Ki-hyun and Lee، نويسنده , , Kang Ro، نويسنده ,
Abstract :
Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells.
Keywords :
Abies holophylla , Spiro compound , Pinaceae , Abietane diterpene
