Author/Authors :
Seidel، نويسنده , , Raphael A. and Schowtka، نويسنده , , Bjِrn and Klopfleisch، نويسنده , , Maurice and Kühl، نويسنده , , Toni and Weiland، نويسنده , , Andreas M.E. Koch، نويسنده , , Alexander and Gِrls، نويسنده , , Helmar and Imhof، نويسنده , , Diana and Pohnert، نويسنده , , Georg and Westerhausen، نويسنده , , Matthias، نويسنده ,
Abstract :
Bilirubin oxidation end products (BOXes) show significant physiological effects and are connected to severe diseases such as subarachnoid hemorrhage induced cerebral vasospasm. BOX B (2-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide) was prepared via a five-step synthesis starting from methyl (4-bromo-3-methyl-5-oxofuran-2(5H)-ylidene)ethanoate that was vinylated and then reacted with NH4OAc, LiOH, (COCl)2, and finally with ammonia yielding Z-BOX B. Derivatives of Z-BOX A and Z-BOX B with [15N]labeled lactam rings were synthesized accordingly.
Keywords :
Bilirubin oxidation end products , lactams , Boxes , pyrroles , BOX B
