Author/Authors :
Hu، نويسنده , , Dong-Bao and Li، نويسنده , , Wen-Xin and Zhao، نويسنده , , Zhen-Zhu and Feng، نويسنده , , Tao and Yin، نويسنده , , Ronghua and Li، نويسنده , , Zheng-Hui and Liu، نويسنده , , Ji-Kai and Zhu، نويسنده , , Hua-Jie، نويسنده ,
Abstract :
Four new highly unsaturated pyranone derivatives A–D (1–4), together with one known compound 5 (−)-nitidon were isolated from cultures of the fungus Junghuhnianitida. Planar structures of the new compounds were elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. Absolute configurations of the new compounds were determined on the basis of biosynthetic considerations and quantum chemistry theory. Compound 1 exhibited almost the same cytotoxic activities as cis-platin.
Keywords :
DFT , matrix , antitumour agents , Junghuhnianitida derivatives , absolute configuration determination
