Title of article
Stereoselective preparation of chiral compounds in Mannich-type reactions of a bicyclic imine and phenols or indole
Author/Authors
Lesley Ann Iwanejko، نويسنده , , Jakub and Wojaczy?ska، نويسنده , , El?bieta and Wojaczy?ski، نويسنده , , Jacek and B?kowicz، نويسنده , , Julia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
6619
To page
6622
Abstract
Mannich-type reactions of a chiral bicyclic imine and various nucleophiles yield the corresponding adducts with good to high diastereoselectivity. The influence of the reaction conditions on the yield and stereochemical outcome is investigated. The configuration of the products is established by 1H NMR spectroscopy, and the major isomers of two adducts are characterized by X-ray crystallography.
Keywords
Bicyclic imines , Mannich reaction , Betti reaction , stereoselectivity
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891315
Link To Document