Why vascular biology matters

Cardiovascular disease has been the leading cause of death for men and women in this country since 1921 and is currently the leading cause of death in the world. Adding to the sense of urgency about disease prevention is the recent finding that the initial lesions of atherosclerotic vascular disease may begin within the first year of life—or even earlier, during fetal growth. However, the pathobiology of atherosclerosis (and in particular, the key role of low-density lipoprotein cholesterol) is now well understood. Activation of 3 major oxidative systems as well as the renin-angiotensin system—all located in the vascular wall—is an early step. In fact, the effects of statins and angiotensin-converting enzyme inhibitors on the vascular wall (improved endothelial function, inhibition of platelet aggregation, and plaque stabilization) are an important mechanism of benefit, independent of their systemic effects. Several very positive trials with these agents have been completed. However, if this information is not incorporated into clinical practice in a timely manner, cardiovascular disease will continue to present a major cause of morbidity and mortality worldwide.