Title of article
A convenient method for synthesis of polyfunctional dihydropyrrole spiro-fused oxindole-2-ones via an organocatalytic tandem Michael/cyclization sequence
Author/Authors
Liu، نويسنده , , Xiong-Wei and Yang، نويسنده , , Jun and Yang، نويسنده , , Chao and Han، نويسنده , , Wenyong and Liu، نويسنده , , Xiong-Li and Zhou، نويسنده , , Ying and Yu، نويسنده , , Zhang-Biao and Yuan، نويسنده , , Wei-Cheng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
7110
To page
7113
Abstract
A new methodology was developed for the synthesis of spirocyclic oxindoles bearing polyfunctional dihydropyrrole units via an organocatalytic tandem Michael/cyclization sequence. Products bearing adjacent quaternary–tertiary stereocenters were smoothly obtained in high yields (up to 97% yield) with excellent diastereoselectivities up to >20/1.
Keywords
Spirocyclic oxindoles , Dihydropyrrole , organocatalysis , Michael/cyclization , Quaternary–tertiary stereocenters
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1893569
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